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Description

Bromazepam is a short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Buy Bromazepam, Lexotan for sale online in Australia Generic NameBromazepamDrugBank Accession NumberDB01558Background One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine. Buy Bromazepam, Lexotan for sale online in Australia TypeSmall MoleculeGroupsApproved, Illicit, InvestigationalStructure Similar Structures Weight Average: 316.153 Monoisotopic: 315.000724604 Chemical Formula C 14 H 10 BrN 3 O Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Bromazepam, like other benzodiazepines, presents a risk of abuse, misuse, and dependence. According to many psychiatric experts, Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action. Buy Bromazepam, Lexotan for sale online in Australia Bromazepam binds to the GABA-A receptor producing a conformational change and potentiating its inhibitory effects. Other neurotransmitters are not influenced. Bioavailability is 84% following oral administration. The time to peak plasma level is 1 – 4 hours. Bromazepam is generally well absorbed after oral administration. Buy Bromazepam, Lexotan for sale online in Australia Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound. Indications and Dosage Oral Anxiety Adult: Initially, 6-18 mg daily in divided doses. Doses up to 60 mg daily have been used. Elderly: Max initial dose: 3 mg daily in divided doses. Special Patient Group Debilitated patients: Max initial dose: 3 mg daily in divided doses. Renal Impairment No dosage adjustment needed. Buy Bromazepam, Lexotan for sale online in Australia Hepatic Impairment Mild to moderate: Initiate therapy conservatively; adjust cautiously. Severe: Contraindicated. Administration May be taken with or without food. Contraindications Patient w/ myasthenia gravis, severe resp insufficiency including chronic obstructive airways disease w/ incipient resp failure, sleep apnoea syndrome. Severe hepatic impairment. Buy Bromazepam, Lexotan for sale online in Australia Special Precautions Patient w/ CV or cerebrovascular disease, pre-existing or chornic resp disease, acute narrow-angle glaucoma, impaired gag reflex, history of alcohol or drug abuse; at risk of falls. Not intended as primary therapy of depression, anxiety and/or psychosis. Avoid abrupt withdrawal . Renal and mild to moderate hepatic impairment. Elderly, debilitated patients. Pregnancy and lactation. Adverse Reactions Drowsiness, dizziness, headache, ataxia, decreased alertness, seizures, tremor, incontinence, anterograde amnesia, confusional state, emotional disturbances, libido disorders, muscle weakness and spasm, depression; behavioural, speech and sleep disorders, restlessness, agitation, delusion, irritability, aggressiveness, nightmares, anger, psychoses, hallucinations, diplopia, pruritus and rash, fatigue, cardiac failure, resp depression, anorexia, GI disturbances (e.g. nausea, vomiting). Buy Bromazepam, Lexotan for sale online in Australia Patient Counseling Information May impair ability to perform activities requiring mental alertness and motor coordination (e.g. operating machinery, driving). Monitoring Parameters Monitor resp, CV and mental status. Periodic monitoring of CBC and LFTs. Overdosage Symptoms: Drowsiness, mental confusion, lethargy, areflexia, apnoea, ataxia, hypotonia, hypotension, cardio-resp depression and coma. Management: Symptomatic and supportive treatment. Admin activated charcoal if taken w/in 1-2 hr. May admin flumazenil cautiously for severe CNS depression. Buy Bromazepam, Lexotan for sale online in Australia