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Description

Indications and Dosage. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Intravenous Moderate to severe pain Adult: As inj: 1-10 mg over 1-2 min, repeated not more often than 4 hrly. As infusion: Initially, 2 mg/hr, increased as necessary. Patient-controlled analgesia (PCA): 0.03 mg/kg, admin w/ a minimum lock-out time of 5 min. Elderly: Give the lowest dose w/ careful titration to pain control. Oral Moderate to severe pain Adult: Initially, 5 mg 4-6 hrly may increase as necessary. Extended-release tab: 5-10 mg 12 hrly. Max: 400 mg/day. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Subcutaneous Moderate to severe pain Adult: As inj: Initially, 5 mg 4 hrly. As infusion: Initially, 7.5 mg daily adjusted according to response. Elderly: Give the lowest dose w/ careful titration to pain control. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Renal Impairment Oral: Mild to moderate: Initial: 2.5 mg 6 hrly. Severe: Contraindicated. Intravenous/Subcutaneous: Mild to moderate: Give the lowest dose w/ careful titration to pain control. Severe: Contraindicated. Hepatic Impairment Oral: Mild: Initial: 2.5 mg 6 hrly. Moderate to severe: Contraindicated. Intravenous/Subcutaneous: Mild: Give the lowest dose w/ careful titration to pain control. Moderate to severe: Contraindicated. Administration Prolonged-Release: May be taken with or without food. 160 mg tab must be taken on an empty stomach. Do not take w/ high fat meals. All strengths: Swallow whole, do not break/chew/crush. Taking broken, chewed or crushed tab leads to rapid release & absorption of a potentially fatal dose of oxycodone. Reconstitution Dilute to 1 mg/mL in 0.9% saline, 5% dextrose or water for inj. Incompatibility Prochlorperazine, cyclizine in concentrations greater than 3 mg/mL or when diluted in 0.9% saline. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Contraindications Resp depression, known or suspected paralytic ileus, acute abdomen, delayed gastric emptying, COPD, cor pulmonale, acute or chronic bronchial asthma, hypercarbia, chronic constipation. Concurrent admin of MAOIs or w/in 2 wk of discontinuation of use. Moderate to severe hepatic and severe renal impairment. Lactation. Special Precautions Patient w/ raised intracranial pressure, hypotension, hypovolaemia, toxic psychosis, biliary tract diseases, pancreatitis, inflammatory bowel disorders, prostatic hypertrophy, adrenocortical insufficiency, history of drug abuse or acute alcoholism, delirium tremens, thyroid dysfunction. Mild to moderate renal and mild hepatic impairment. Pregnancy. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Adverse Reactions Nausea, constipation, vomiting, resp depression, headache, pruritus, insomnia , dizziness, asthenia, somnolence, abdominal pain, chills and fever, hypotension, anorexia, diarrhoea, dyspepsia, dysphagia, anxiety, nervousness, tremor, vasodilation, cough, dyspnoea, rash. Pregnancy Category (US FDA) PO: B (Prolonged use may cause neonatal opioid withdrawal syndrome.) Patient Counseling Information May impair ability to drive or operate machinery. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Monitoring Parameters Monitor pain relief, resp and mental status, BP; signs of misuse, abuse, and addiction; signs or symptoms of hypogonadism or hypoadrenalism. Overdosage Symptoms: Pin-point pupils, resp depression, hypotension . Circulatory failure and somnolence progressing to stupor or deepening coma, skeletal muscle flaccidity, bradycardia and death may occur in more severe cases. Management: Maintain adequate respiration and employ supportive measures (including oxygen and vasopressors) in the management of circulatory shock and pulmonary oedema. Cardiac arrest or arrhythmias may require cardiac massage or defibrillation. Naloxone may be used as an antidote. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Drug Interactions Potentiates the effects of tranquilisers, anaesth, hypnotics, anti-depressants, sedatives, phenothiazines, neuroleptic drugs, other opioids, muscle relaxants and antihypertensives. Concurrent admin of quinidine, a CYP2D6 inhibitor may cause an increase in serum levels and elimination half-life of oxycodone. Cimetidine and CYP3A inhibitors (e.g. ketoconazole, erythromycin) may inhibit the metabolism of oxycodone. Potentially Fatal: Concurrent admin of MAOIs may result to CNS excitation or depression w/ hypertensive or hypotensive crisis. Food Interaction May potentiate the CNS depressant effect of alcohol. Buy Oxycodone online, Oxycontin 30mg for sale in Australia Action Description: Oxycodone is a synthetic phenanthrene-derivative opiate agonist. It binds to opiate receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain. It produces generalised CNS depression. Onset: 10-15 min (immediate-release). Duration: 3-6 hr (immediate-release); ≤12 hr (extended-release). Pharmacokinetics: Absorption: Absorbed from the GI tract. Bioavailability: Approx 60-87%. Distribution: Crosses the placenta and enters breast milk. Volume of distribution: 2.6 L/kg. Plasma protein binding: Approx 45%. Metabolism: Metabolised via glucuronidation to noroxycodone by CYP3A isoenzymes and to a lesser extent, to oxymorphone by CYP2D6. Excretion: Via urine as unchanged drug. Elimination half-life: 2-4 hr. Buy Oxycodone online, Oxycontin 30mg for sale in Australia